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Obese male mice father offspring with higher levels of body fat

In a new Ohio University study, researchers found that male mice who were fed a high-fat diet and became obese were more likely to father offspring who also had higher levels of body fat. The effect was observed primarily in male offspring, despite their consumption of a low-fat diet. "We've identified a number of traits that may affect metabolism and behavior of offspring dependent on the ...
Latos takes on Bucs hoping to stay undefeated

On Monday, the Pirates dropped the first game of their four-game set against the Reds at Great American Ball Park. But don't worry, it's all part of their plan. In each of their five four-game series this season (counting a two-game home and home with the Tigers), the Bucs lost the first game and came back to win the next three. They'll try to continue this strange trend, one ...
Powered Paraglider Crashes During Takeoff

The West Jefferson Post of the Ohio State Highway Patrol is investigating a paraglider crash in Madison County. The Madison County Sheriff's Office called troopers around a possible plane crash in the 3700 block of West Jefferson Kiousville Road in Lilley Chapel around 7:45 p.m.Troopers found the pilot, Christopher R. Baker, 32, and his damaged paraglider. Troopers said Baker, who is from ...
Powell Police Investigating Rash Of Vehicle Break-ins

The Powell Police Department is investigating a rash of vehicle break-ins near Broadsworth Court during the weekend.Kyle Sopko says the suspects triggered his car alarm and woke him up. "At first, I thought maybe I had set off my car alarm. Maybe I had rolled onto my keys and I hadn't woken up," he said.Sopko walked outside and discovered his car was a mess."Where the glove ...
Carrasco strong in Indians tough loss to KC

KC@CLE: Santana puts Indians on the board with homer CLEVELAND -- Indians starter Carlos Carrasco pitched well enough to earn his first victory of 2013, but the bullpen let things get away and the offense couldn't keep up. Carrasco -- making his first start since serving a seven-game suspension -- left with one out and a man on second in the eighth inning, while the Indians led by one ...

Movie Review

Clueless [Blu-Ray]

Amy Heckerlings Clueless offers some of the best humor, entertainment, and social insight the teen comedy genre has to offer. And, while that may sound like damning praise, I do not hesitate to suggest that the teen comedy is one of the most unfairly maligned and underappreciated genres ... ...

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Four homers back Leake as Reds win series opener

PIT@CIN: Frazier's solo shot puts the Reds in front CINCINNATI -- Mike Leake continued a stingy streak of pitching and was supported by home runs from Zack Cozart, Todd Frazier, Joey Votto and Jay Bruce for a 4-1 victory over the Pirates on Monday at Great American Ball Park. Leake pitched seven innings, allowing one run on six hits and one walk with three strikeouts. Over his last ...
Ohio day-care operator allegedly gave kids medicine-laced pancakes

An Ohio day-care operator fed children in her care pancakes laced with medication to make them drowsy, authorities allege. Caterpillar Clubhouse owner Tammy E. Eppley, 37, of Westerville is charged with six counts of endangering children, The Columbus Dispatch reported Monday. Police allege Eppley mixed various medications and supplements, including melatonin and antihistamine allergy ...
Mount Vernon Police Investigate Stolen Sewer Grates

Thieves in Knox County are targeting storm sewer grates. Mayor Richard Mavis says the city has lost nearly 30 grates this spring and up to 50 to 60 grates have been stolen countywide. Officials believe the thieves are taking them to sell for scrap. The city is working on ways to make the grates more difficult to steal, such as spot-welding them in place or installing a locking metal strap. ...
Tribes Perez eyeing Friday return to bullpen

Email CLEVELAND -- Closer Chris Perez believes he'll be ready to return to Cleveland's bullpen on Friday after just one more rehab appearance. Perez is scheduled to throw an inning for Double-A Akron on Tuesday. This past Sunday, he tossed a scoreless frame for Class A Lake County, allowing two hits and notching one strikeout. Perez was placed on the 15-day disabled list on May 27 ...
Francona favors pitchers comfort with safety

Email CLEVELAND -- A few days after Rays right-hander Alex Cobb was struck in the right ear by a fast-moving liner, Indians manager Terry Francona discussed the delicate safety issue facing Major League Baseball. Francona couldn't say whether incidents such as those involving Cobb or J.A. Happ or Brandon McCarthy are happening with more frequency, or if they're simply being noticed ...

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Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

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Iran's president-elect was speaking after his historic election victory.

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Fairmont Hotel Vancouver, Canada

A grand traditional hotel, in the heart of downtown Vancouver. The hotel is one of three Fairmonts in this Canadian-gateway ...

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Obese male mice father offspring with higher levels of body fat

In a new Ohio University study, researchers found that male mice who were fed a high-fat diet and became obese were more likely to father offspring who also had higher levels of body fat.

The effect was observed primarily in male offspring, despite their consumption of a low-fat diet.

"We've identified a number of traits that may affect metabolism and behavior of offspring dependent on the pre-conception diet of the father," said Felicia Nowak, an associate professor of biomedical sciences in Ohio University's Heritage College of Osteopathic Medicine who is lead author on the study.

The researchers point to epigenetics-the way genes are expressed, as opposed to mutations in DNA that are "hard-wired into the genes"-as a possible cause of these inherited traits. Because gene expression is impacted by environmental and lifestyle factors, this finding suggests that individuals with obese fathers may be able to proactively address health concerns.

The Ohio University team studied the impact of the high-fat diet only with male mice parents, as most of the previous research had focused on female mice parents.

To conduct the study, the researchers fed male mice a high-fat diet for 13 weeks before mating. ...