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Obese male mice father offspring with higher levels of body fat

In a new Ohio University study, researchers found that male mice who were fed a high-fat diet and became obese were more likely to father offspring who also had higher levels of body fat. The effect was observed primarily in male offspring, despite their consumption of a low-fat diet. "We've identified a number of traits that may affect metabolism and behavior of offspring dependent on the ...
Mount Vernon Police Investigate Stolen Sewer Grates

Thieves in Knox County are targeting storm sewer grates. Mayor Richard Mavis says the city has lost nearly 30 grates this spring and up to 50 to 60 grates have been stolen countywide. Officials believe the thieves are taking them to sell for scrap. The city is working on ways to make the grates more difficult to steal, such as spot-welding them in place or installing a locking metal strap. ...
Tribes Perez eyeing Friday return to bullpen

Email CLEVELAND -- Closer Chris Perez believes he'll be ready to return to Cleveland's bullpen on Friday after just one more rehab appearance. Perez is scheduled to throw an inning for Double-A Akron on Tuesday. This past Sunday, he tossed a scoreless frame for Class A Lake County, allowing two hits and notching one strikeout. Perez was placed on the 15-day disabled list on May 27 ...
Francona favors pitchers comfort with safety

Email CLEVELAND -- A few days after Rays right-hander Alex Cobb was struck in the right ear by a fast-moving liner, Indians manager Terry Francona discussed the delicate safety issue facing Major League Baseball. Francona couldn't say whether incidents such as those involving Cobb or J.A. Happ or Brandon McCarthy are happening with more frequency, or if they're simply being noticed ...
Cingrani to stick around will pitch out of bullpen

Email CINCINNATI -- Lefty pitcher Tony Cingrani doesn't know what his role will be and doesn't particularly care if it means he's staying in the big leagues with the Reds. Cingrani was called up from Triple-A Louisville to start vs. the Cubs on Tuesday in place of injured ace Johnny Cueto. When Cueto successfully returned to face the Brewers in Sunday's 5-1 victory, Cingrani ...

Movie Review

Clueless [Blu-Ray]

Amy Heckerlings Clueless offers some of the best humor, entertainment, and social insight the teen comedy genre has to offer. And, while that may sound like damning praise, I do not hesitate to suggest that the teen comedy is one of the most unfairly maligned and underappreciated genres ... ...

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Cueto OK after DL return but time will tell

Email CINCINNATI -- The first time that Reds ace Johnny Cueto returned from the disabled list after suffering a strained right lat muscle, he made three successful starts. One of them was an eight-inning outing to beat the Pirates. It was after that game that Cueto returned to the DL with a recurrence of the injury. On Monday, the day after Cueto successfully returned again with six innings and ...
First-round pick Ervin readying for pro debut

Email CINCINNATI -- Outfielder and Reds 2013 first-round Draft pick Phillip Ervin, who signed his contract on June 10, will begin his pro career at Rookie-level Billings. The Mustangs' season begins on Thursday. Ervin is one of 16 Draft selections that have already signed. Others included the third-round pick Mark Armstrong, a right-handed pitcher, and Chad Jones, a left-handed pitcher ...
Tribe playing it safe with Swishers shoulder

Email CLEVELAND -- For the second day in a row, Nick Swisher wasn't in the Tribe's starting lineup, held out to nurse an ailing left shoulder as the Kansas City Royals arrived on Monday for a three-game series. Indians manager Terry Francona said Swisher's shoulder was examined on Sunday and the results revealed no structural changes. Swisher received a cortisone shot on Monday. ...
OH man sentenced in case involving false charity

COLUMBUS, Ohio (AP) -- Ohio Attorney General Mike DeWine says a man who solicited money he falsely claimed would go to help veterans has been sentenced to 2 1/2 years in ...
Former Deputy Says He Had Sexual Relationship With Student

A former Richland County Sheriff’s deputy said he had a sexual relationship with a student while he was teaching at Pioneer Career and Technology Center.According to ...

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Our nuclear programmes are completely transparent. But we are ready to show greater transparency and make clear for the whole world that the steps of the Islamic Republic of Iran are completely within international frameworks. The sanctions are unfair, the Iranian people are suffering, and our (nuclear) activities are legal. These sanctions are illegal and only benefit Israel.

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Iran's president-elect was speaking after his historic election victory.

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Fairmont Hotel Vancouver, Canada

A grand traditional hotel, in the heart of downtown Vancouver. The hotel is one of three Fairmonts in this Canadian-gateway ...

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Obese male mice father offspring with higher levels of body fat

In a new Ohio University study, researchers found that male mice who were fed a high-fat diet and became obese were more likely to father offspring who also had higher levels of body fat.

The effect was observed primarily in male offspring, despite their consumption of a low-fat diet.

"We've identified a number of traits that may affect metabolism and behavior of offspring dependent on the pre-conception diet of the father," said Felicia Nowak, an associate professor of biomedical sciences in Ohio University's Heritage College of Osteopathic Medicine who is lead author on the study.

The researchers point to epigenetics-the way genes are expressed, as opposed to mutations in DNA that are "hard-wired into the genes"-as a possible cause of these inherited traits. Because gene expression is impacted by environmental and lifestyle factors, this finding suggests that individuals with obese fathers may be able to proactively address health concerns.

The Ohio University team studied the impact of the high-fat diet only with male mice parents, as most of the previous research had focused on female mice parents.

To conduct the study, the researchers fed male mice a high-fat diet for 13 weeks before mating. ...