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| "This historic moment comes at a time of great uncertainty for many Americans. We have now been through nearly a decade of war. We have endured a long and painful recession. And sometimes in the midst of these storms, the future that we are trying to build for our nation - a future of lasting peace and long-term prosperity - may seem beyond our reach" |
| Barack Obama |
| US President Obama was making a national address Tuesday to mark the end of the combat mission in Iraq |
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Ohio Standard
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Culprit behind severe allergic asthma discovered
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Researchers from Cincinnati Children's Hospital Medical Center have identified the key culprit behind severe asthma-like symptoms in mice.
The disease can be triggered in susceptible people by a variety of environmental contaminants - such as cigarette smoke, allergens and airborne pollution.
Dr. Marsha Wills-Karp and her colleagues have identified the pro-inflammatory protein, interleukin-17 (IL-17A), as the molecular tipping point that upsets a delicate balance between underlying mild disease and more severe asthma, reports Nature.
Airway exposure to environmental allergens causes dysfunctional regulation of a gene called complement factor 3 (C3). This leads to overzealous production of IL-17A by airway cells and sets off what the scientists describe as an "amplification loop," when IL-17A in turn induces more C3 production at the airway surface.
The amplification loop perpetuates increasing inflammatory responses as well as airway hyper-responsiveness and airflow obstruction.
As the team continues their research, they will study the relationship between C3 and IL-17A in severe asthmatics, and explore the effectiveness of targeting either the C3 or IL-17A pathways for the treatment of severe asthma.
The study is published in the latest Nature Immunology. (ANI)
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Ohio Standard
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Every minute of every day our news editors canvass the issues, and stories making the news to provide our readers with a broad and in-depth coverage of what's happening in the world.
Our first priority is the state. We specialise in Ohio news. From Cleveland to Cincinatti, we're on the lookout day and night to keep track of issues making the news. We also strive to keep abreast of national news.
Breaking stories out of the continental United States usually break first on the Ohio Standard. Neighbouring states and key cities too often feature on our news pages.
We also provide a whole lot of other content you'd expect from any newspaper including international sports coverage and local Ohio weather forecasts.
We also provide readers with an opportunity to engage in newsmaking by voting on major stories in the news, and following how other readers are viewing the issues. Our news polls are regularly updated, and attract thousands of voters over each week they're conducted.
Our business writers too work hard to keep you abreast of what's happening in the markets, not only in the U.S. but across the globe. We work around the clock to post stories from major financial centers like Tokyo, Paris, London, and of course New York, where we have extensive coverage of the major indices, particularly the Dow Jones, Nasdaq, S&P and Russell 2000. |
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| Le Meridien Noumea, New Caledonia |

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This deluxe hotel is reputedly the finest in New Caledonia. The drive from Tontouta international airport is 45 minutes and...
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